Potassium Carbonate → HCID 76021281, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(5-hydroxymethyl-pyrrolidin-3-yl)-methyl-amino]-thiazol-4-one (20 mg, 0.034 mmol) (Example 43) (30 mg, 0.051 mmol) in DMF (1 mL) was added potassium carbonate (11 mg, 0.072 mmol) followed by 2-Bromo-acetamide (30 mg, 0.22 mmol). The reaction mixture was stirred at 70° C. for 1 hour and partitioned between water and dichloromethane. The dichloromethane layer was washed with brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid. The crude solid was purified via flash chromatography (100% ethyl acetate) to yield the title compound (24 mg, 72%).

Provenance & Evidence