Diisopropylethylamine → HCID 76774448, compound

Participants

Reaction Steps

To a solution of 4-({5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-methyl-amino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (0.066 g, 0.1 mmol) and methoxyamine hydrochloride (0.014 g, 0.15 mmol) in DMF (2 mL) was added EDC hydrochloride (0.03 g, 0.15 mmol) followed by DIPEA (0.3 mL, 1.72 mml). The reaction mixture was stirred at room temperature for 16 hours and partitioned between water and dichloromethane. The dichloromethane layer was washed with brine, dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid. The crude solid was purified via flash chromatography (100% ethyl acetate) to yield the title compound.

Provenance & Evidence