反应详情

温度

85 °C

A mixture of 2-(4-Methyl-3-trifluoromethyl-phenyl)-propan-2-ol (0.436 g, 2 mmol), N-Bromosuccinimide (356 mg, 2 mmol) and benzoyl peroxide (15 mg) in CCl4 (8 mL) was stirred at 85° C. for 16 hrs. The reaction mixture was then partitioned between saturated aqueous NaHCO3 and DCM. DCM layer was dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield a crude solid which was purified via flash chromatography (15% EtOAc in n-heptane) to yield the title compound as a solid (450 mg, 76%)

1. customThe reaction mixture was then partitioned between saturated aqueous NaHCO3 and DCM
2. dry with materialDCM layer was dried over Na2SO4
3. filtrationfiltered
4. customthe solvent evaporated in vacuo
5. customto yield a crude solid which
6. customwas purified via flash chromatography (15% EtOAc in n-heptane)