(R)-2'-bromo-7'-(neopentyloxy)-5H-spiro[oxazole-4,9'-xanthen]-2-amine → (S)-2'-(neopentyloxy)-5H-spiro[oxazole-4,9'-xanthen]-2-amine

Participants

Reaction Steps

A mixture of (R)-2′-bromo-7′-(neopentyloxy)-5H-spiro[oxazole-4,9′-xanthen]-2-amine (0.0500 g, 0.120 mmol), ethanol (2 mL), and palladium 10% on activated carbon (0.013 g, 0.012 mmol) was stirred under 1 atm of H2 gas overnight. The catalyst was filtered through celite and the filtrate was concentrated in vacuo to provide (S)-2′-(neopentyloxy)-5H-spiro[oxazole-4,9′-xanthen]-2-amine as a white solid.

Provenance & Evidence