HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1970407Generated: November 4, 2026
Benzeneethanamine, alpha-methyl-, phosphate (1:1) → HCID 45254328, compound
https://huagongshe.com/reaction/1970407
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzeneethanamine, alpha-methyl-, phosphate (1:1) | HCID 62885 | — |
| Reactant | 2-[(1E)-3,3-Dimethyl-1-buten-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 11769738 | — |
| Reactant | Potassium phosphate, tribasic, monohydrate | HCID 22031701 | — |
| Reactant | HCID 87321994 | HCID 87321994 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 45254328 | HCID 45254328 | — |
Reaction Steps
A mixture of (S)-3-chloro-7-(pyrimidin-5-yl)-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (0.967 g, 2.64 mmol), trans-(3,3-dimethylbutenyl)boronic acid pinacol ester (1.389 g, 6.61 mmol), AmPhos (0.094 g, 0.132 mmol), and potassium phosphate hydrate (1.218 g, 5.29 mmol) in 10 mL dioxane/water (1:1) was heated in the microwave at 130° C. for 1 h. After cooling to rt, the reaction was concentrated and the residue purified by silica gel chromatography using 0-5% MeOH/DCM to give (S,E)-3-(3,3-dimethylbut-1-enyl)-7-(pyrimidin-5-yl)-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine. Found MS: MH+=414.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426447B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-3168c5754b0140df92384e5853fc2cbb |
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| Source note | uspto-grants-2013_04 |
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