反应详情

To a solution of 20.9 g 4-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid ethyl ester in 120 ml ethanol were added 2.0 g Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (3 bar) for 12 h. The reaction mixture was filtrated over a plug of Celite, washed with ethanol and concentrated to give the crude product which was not further purified. Yield: 13.6 g colorless oil.

1. filtrationThe reaction mixture was filtrated over a plug of Celite
2. washwashed with ethanol
3. concentrationconcentrated