HCID 66854903, compound → HCID 66854483, compound

Participants

Reaction Steps

To a solution of 4.800 g 4-((S)-2-{[5-Benzyloxycarbonylmethoxy-1-(3,4-difluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid ethyl ester in 60 ml ethyl acetate were added under argon 0.7 g Pd/C (10%) and the suspension was stirred under an atmosphere of hydrogen (3 bar) for 16 h. The suspension was filtered over a plug of Celite® and washed with ethyl acetate. The crude product obtained after evaporation of the solvent was dried under vacuo. Yield: 4.0 g.

Provenance & Evidence