HCID 66854463, compound → (S)-4-Amino-5-[4-(3-methoxy-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester

HRID 1970461Notes

Reaction equation

HRID 1970461 reaction equation
[C:1]([O:5][C:6](=[O:37])[CH2:7][CH2:8][C@H:9]([NH:26]C(OCC1C=CC=CC=1)=O)[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:14][CH2:13]1)=[O:11])([CH3:4])([CH3:3])[CH3:2]>CCO.[Pd]>[C:1]([O:5][C:6](=[O:37])[CH2:7][CH2:8][C@H:9]([NH2:26])[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:14][CH2:13]1)=[O:11])([CH3:2])([CH3:4])[CH3:3]

Participants

4

Reactant 1

HCID 66854463HCID 66854463, compound

Product 1

HCID 66854834(S)-4-Amino-5-[4-(3-methoxy-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 4.00 g (S)-4-benzyloxycarbonylamino-5-[4-(3-methoxy-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester in 60 ml EtOH were added 0.7 g Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (3 bar) for 12 h. The reaction mixture was filtrated over Celite and washed with EtOH. The title compound was used without further purification after evaporation of the solvent. Yield: 2.90 g.

Workup

  1. filtrationThe reaction mixture was filtrated over Celite
  2. washwashed with EtOH
  3. customThe title compound was used without further purification
  4. customafter evaporation of the solvent

Sources & evidence

ORD record
ord-d5febccebe5b41a3bc0278ba90069a36
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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