HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Amino-1-N-Cbz-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate | HCID 21981786 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Amino-1-N-Cbz-piperidine | HCID 17846640 | — |
Reaction Steps
A solution of 4.4 g 4-tert-butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester in 90 ml dichloromethane was stirred in the presence of 10 ml TFA for 3 h. The product was obtained after evaporation of the solvent and used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426420B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-cd86b1c580a74b3f83f43e38f432b119 |
| Source note | uspto-grants-2013_04 |