HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Butyl chloroformate | HCID 61140 | — |
| Reactant | 4-Amino-1-N-Cbz-piperidine | HCID 17846640 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester | HCID 66855950 | — |
Reaction Steps
To a solution of 4.4 g 4-amino-piperidine-1-carboxylic acid benzyl ester hydrotrifluoroacetate and 5.3 ml triethylamine in 100 ml dichloromethane were added 1.8 ml butylchloroformate dropwise at 0° C. The suspension was stirred for 12 h, diluted with dichloromethane and washed with 0.1 M HCl and aqueous NaHCO3. The crude product was purified by flash chromatography on silica using ethyl acetate/heptan 1:2 as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426420B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-fdb717f312624ba687c96eb59364e597 |
| Source note | uspto-grants-2013_04 |