4-Butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester → Piperidin-4-yl-carbamic acid butyl ester

HRID 1970465Notes

Reaction equation

HRID 1970465 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:19])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CCO.[Pd]>[CH2:21]([O:20][C:18](=[O:19])[NH:17][CH:14]1[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]1)[CH2:22][CH2:23][CH3:24]

Participants

4

Reactant 1

HCID 668559504-Butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester

Product 1

HCID 15676963Piperidin-4-yl-carbamic acid butyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 1.8 g 4-butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester in 60 ml EtOH were added 200 mg Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (1 bar) for 2 h. The reaction mixture was filtrated over a plug of Celite and washed with EtOH to give the product as colorless oil after evaporation of the solvent.

Workup

  1. filtrationThe reaction mixture was filtrated over a plug of Celite
  2. washwashed with EtOH

Sources & evidence

ORD record
ord-34306e1139604cc5957aabcb990cad9c
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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