HCID 66854405, compound → HCID 66854394, compound

HRID 1970466Notes

Reaction equation

HRID 1970466 reaction equation
[C:1]([O:5][C:6](=[O:37])[CH2:7][CH2:8][C@H:9]([NH:26]C(OCC1C=CC=CC=1)=O)[C:10]([N:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19]([O:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:20])[CH2:14][CH2:13]1)=[O:11])([CH3:4])([CH3:3])[CH3:2]>CCO.[Pd]>[C:1]([O:5][C:6](=[O:37])[CH2:7][CH2:8][C@H:9]([NH2:26])[C:10]([N:12]1[CH2:13][CH2:14][CH:15]([NH:18][C:19]([O:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:20])[CH2:16][CH2:17]1)=[O:11])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 66854405HCID 66854405, compound

Product 1

HCID 66854394HCID 66854394, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 0.91 g (S)-4-Benzyloxycarbonylamino-5-(4-butoxycarbonylamino-piperidin-1-yl)-5-oxo-pentanoic acid tert-butyl ester in 10 ml EtOH were added 0.2 g Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (3 bar) for 12 h. The reaction mixture was filtrated over Celite and washed with EtOH. The title compound was used without further purification after evaporation of the solvent. Yield: 0.67 g.

Workup

  1. filtrationThe reaction mixture was filtrated over Celite
  2. washwashed with EtOH
  3. customThe title compound was used without further purification
  4. customafter evaporation of the solvent

Sources & evidence

ORD record
ord-8e6ab4a0083e4548b6821b83f33149b9
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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