1-Hydroxybenzotriazole → HCID 66855276, compound

Participants

Reaction Steps

To a solution of 1.14 g 4-{(S)-4-tert-butoxycarbonyl-2-[(5-carboxymethoxy-1-phenyl-1H-pyrazole-3-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester in 10 ml DMF were added 719 mg HOBt, 900 mg EDC, 1.6 ml DIPEA and 1.50 g pyrrolidine-3-carboxylic acid benzyl ester hydrotrifluoroacetate. After stirring for 12 h the reaction mixture was diluted with ethyl acetate, washed with aqueous LiCl (4%) and saturated aqueous NaHCO3. The crude product obtained after evaporation of the solvent was used without further purification. Yield: 2.32 g.

Provenance & Evidence