HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl succinimido carbonate → (R)-4-Boc-1-Cbz-2-methyl-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl succinimido carbonate | HCID 83172 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (R)-1-Boc-3-methylpiperazine | HCID 2756811 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | (R)-4-Boc-1-Cbz-2-methyl-piperazine | HCID 53886770 | — |
Reaction Steps
A mixture of 2.4 g (R)-4-N-Boc-2-methyl-piperazine, 3.5 g N-(Benzyloxycarbonyl-oxy)succinimide and 2.0 g NaHCO3 in 10 ml dioxane/water 1/1 was stirred for 12 h. The mixture was diluted with ethyl acetate, the phases separated and the organic phase washed with water, saturated aqueous NaHCO3, 0.1 M HCl and brine. The crude product obtained after drying over MgSO4 and evaporation of the solvents was used in the subsequent reaction. Yield: 4.3 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426420B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-044d921f36384ffab93d584a1053dac7 |
| Source note | uspto-grants-2013_04 |