Lithium Hydroxide → HCID 66855209, compound

Participants

Reaction Steps

To a solution of 881 mg 4-[(S)-4-tert-butoxycarbonyl-2-({5-[2-((S)-4,4-difluoro-2-methoxy-carbonyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester in 24 ml THF and 6 ml H2O were added 30 mg LiOH at 0° C. The reaction mixture was allowed to warm to RT and was then stirred for 3 h before being acidified by using Amberlite IR-120. The reaction mixture was filtered, washed with MeOH and the combined wash solutions concentrated to give the crude product which was used in the subsequent reaction. Yield: 711 mg.

Provenance & Evidence