HCID 178430878, compound → HCID 178430879, compound

HRID 1970567Notes

Reaction equation

HRID 1970567 reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]1[NH:17][CH:18]=[C:19]([CH3:21])[N:20]=1)=O)C1C=CC=CC=1>CCO.[Pd]>[CH3:21][C:19]1[N:20]=[C:16]([C@@H:12]2[CH2:13][CH2:14][CH2:15][NH:11]2)[NH:17][CH:18]=1

Participants

4

Reactant 1

HCID 178430878HCID 178430878, compound

Product 1

HCID 178430879HCID 178430879, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 100 mg (S)-2-(4-Methyl-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester in 5 ml EtOH was stirred in the presence of 15 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 2 h. The reaction mixture was filtered over a plug of Celite and washed with EtOH. Evaporation of the solvent gave the product as colorless oil.

Workup

  1. filtrationThe reaction mixture was filtered over a plug of Celite
  2. washwashed with EtOH
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-e5ae2e47249140faa44585aab367a610
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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