HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 66855555, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | N-(tert-Butoxy(hydroxy)methylidene)-O-ethylserine | HCID 15058451 | — |
| Reactant | Butyl piperazine-1-carboxylate | HCID 21963126 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66855555 | HCID 66855555 | — |
Reaction Steps
To a solution of 146 mg (S)-N-Boc-2-amino-3-ethoxypropionic acid in 2 ml DMF were added 0.34 ml N-ethylmorpholine, 200 mg 1-butoxycarbonylpiperazine hydrotrifluoroacetate and 219 mg TOTU. After stirring for 12 h it was added saturated aqueous NaHCO3 and the mixture was loaded on a Chem Elut® cartridge, the crude product being eluted with ethyl acetate. The solution was concentrated, the residue obtained dissolved in 5 ml dichloromethane and stirred in the presence of 1 ml TFA. After 12 h stirring it was concentrated and the residue codistilled twice with toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426420B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d164dcccd3664fa18f6c707d0f810c28 |
| Source note | uspto-grants-2013_04 |