HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → HCID 66857076, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | HCID 88804 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66857076 | HCID 66857076 | — |
Reaction Steps
To a solution of 2.00 g (2S,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester in 20 ml DMF were added 1.18 g HOAT, 615 mg cyclobutylamine and 1.66 g EDC. After stirring for 12 h saturated NaHCO3 solution (3 ml) was added and the mixture passed through a Chem Elute® cartridge eluting with DCM. The crude product obtained after evaporation of the solvent was purified by filtering over a short plug of silica eluting with ethyl acetate. Yield: 1.22 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426420B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0ac5799e84bd47729d4211d486e5efd4 |
| Source note | uspto-grants-2013_04 |