2(3H)-Benzoxazolone, 6-acetyl- → 6-(1-Hydroxyethyl)-1,3-benzoxazol-2-ol

HRID 1970886Notes

Reaction equation

HRID 1970886 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]2[NH:8][C:9](=[O:11])[O:10][C:6]=2[CH:5]=1)(=[O:3])[CH3:2]>CO.[Pd]>[OH:3][CH:1]([C:4]1[CH:13]=[CH:12][C:7]2[NH:8][C:9](=[O:11])[O:10][C:6]=2[CH:5]=1)[CH3:2]

Participants

4

Reactant 1

HCID 6890542(3H)-Benzoxazolone, 6-acetyl-

Product 1

HCID 412276-(1-Hydroxyethyl)-1,3-benzoxazol-2-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.5 g (14.1 mmol) of 6-acetyl-3H-benzoxazol-2-one are dissolved in 150 ml of methanol, and the mixture is stirred for 5 h with 2.5 g of palladium on activated carbon (5%) and under a hydrogen atmosphere. The catalyst is filtered off with suction and rinsed with methanol. The filtrate is evaporated to dryness and dried in vacuo.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. washrinsed with methanol
  3. customThe filtrate is evaporated to dryness
  4. customdried in vacuo

Sources & evidence

ORD record
ord-a40a43e2f9344dd3b784f37e7369369c
Source dataset
uspto-grants-2013_04
Patent number
US08431572B2

Reaction notes

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