4-Piperidineethanol → HCID 135995049, compound

HRID 1970896Notes

Reaction equation

HRID 1970896 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][C:5]1[NH:6][C:7](=[O:15])[C:8]([C:13]#[N:14])=[C:9](SC)[N:10]=1.[NH:20]1[CH2:25][CH2:24][CH:23]([CH2:26][CH2:27][OH:28])[CH2:22][CH2:21]1>C(#N)C>[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][C:5]1[NH:6][C:7](=[O:15])[C:8]([C:13]#[N:14])=[C:9]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH2:27][OH:28])[CH2:22][CH2:21]2)[N:10]=1

Participants

4

Reactant 2

HCID 739534-PiperidineethanolHCID 58407903HCID 58407903, compound

Product 1

HCID 135995049HCID 135995049, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.1 g (0.37 mmol) of 2-(2-fluorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile is heated with 0.14 g (1.1 mmol) of 2-(4-piperidinyl)ethan-1-ol in 3 ml of acetonitrile at 90° C. under argon for six days. After cooling to room temperature, the crude product is purified by preparative HPLC. 31 mg (24% of theory) of the title compound are obtained as a colourless solid.

Workup

  1. customthe crude product is purified by preparative HPLC

Sources & evidence

ORD record
ord-b9f2246273b545e995dc947d1f74d7bd
Source dataset
uspto-grants-2013_04
Patent number
US08431573B2

Reaction notes

Loading…