HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Methylpiperazine → 2-(3-Chlorobenzyl)-4-(4-methylpiperazin-1-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | 2-(3-Chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407802 | — |
| Produkt | 2-(3-Chlorobenzyl)-4-(4-methylpiperazin-1-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 135995012 | — |
Reaktionsschritte
In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methyl-sulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 343 mg (3.43 mmol) of N-methylpiperazine to give 101 mg (84% of theory) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08431573B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-f66ea79f553d49238f68d07967da7a3c |
| Quellennotiz | uspto-grants-2013_04 |