HCID 15766443, compound → HCID 44197929, compound

HRID 1970948Notes

Reaction equation

HRID 1970948 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[N:10]=2)[N:3]=1.[CH:16]([N:19]1[CH2:24][CH2:23][N:22]([C:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:34]=[N:35][CH:36]=[C:37](B4OC(C)(C)C(C)(C)O4)[CH:38]=3)=[CH:29][CH:28]=2)=[O:26])[CH2:21][CH2:20]1)([CH3:18])[CH3:17]>>[Cl:8][C:6]1[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[N:10]=2)[N:3]=[C:2]([C:37]2[CH:38]=[C:33]([C:30]3[CH:29]=[CH:28][C:27]([C:25]([N:22]4[CH2:21][CH2:20][N:19]([CH:16]([CH3:18])[CH3:17])[CH2:24][CH2:23]4)=[O:26])=[CH:32][CH:31]=3)[CH:34]=[N:35][CH:36]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 15766443HCID 15766443, compoundHCID 68754506HCID 68754506, compound

Product 1

HCID 44197929HCID 44197929, compound

Procedure

This compound is prepared from 4,6-dichloro-2-(6-methyl-pyridin-2-yl)-pyrimidine (Int. B) and (4-isopropylpiperazin-1-yl)(4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)phenyl)methanone (Int. I) analogously to Example 1: [M+H]+=513/515 as a brown solid.

Sources & evidence

ORD record
ord-91012134bbf0428f9f25a9b1f14497b4
Source dataset
uspto-grants-2013_04
Patent number
US08431578B2

Reaction notes

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