Methanol → HCID 44197796, compound

HRID 1970949Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[N:5]=[C:4]([C:15]2[CH:16]=[C:17]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([N:29]4[CH2:34][CH2:33][N:32]([CH:35]([CH3:37])[CH3:36])[CH2:31][CH2:30]4)=[O:28])=[CH:23][CH:22]=3)[CH:18]=[N:19][CH:20]=2)[CH:3]=1.[CH3:38][OH:39]>>[CH:35]([N:32]1[CH2:33][CH2:34][N:29]([C:27]([C:24]2[CH:25]=[CH:26][C:21]([C:17]3[CH:18]=[N:19][CH:20]=[C:15]([C:4]4[CH:3]=[C:2]([O:39][CH3:38])[N:7]=[C:6]([C:8]5[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=5)[N:5]=4)[CH:16]=3)=[CH:22][CH:23]=2)=[O:28])[CH2:30][CH2:31]1)([CH3:37])[CH3:36]

Participants

Reactant 2

HCID 887Methanol

HCID 44197929HCID 44197929, compound

Product 1

HCID 44197796HCID 44197796, compound

Procedure

This compound is prepared from (4-{5-[6-chloro-2-(6-methyl-pyridin-2-yl)-pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-(4-isopropyl-piperazin-1-yl)-methanone (Ex. 7) and methanol analogously to Example 2: [M+H]+=509 as a white solid.

Sources & evidence

ORD record: ord-fdd490d5c7c2464caef5c455ece024b3
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08431578B2

Reaction notes

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