Ammonium Chloride → HCID 59543159, compound

Participants

Reaction Steps

To a stirred solution of N-[(1E)-3-hydroxy-3-methylbutylidene]-2-methylpropane-2-sulfinamide (0.6 g, 2.9 mmol) in DCM (18 mL) was added cyclopropylmagnesium bromide (0.5 M in THF, 17.5 mL, 8.8 mmol) at −78° C. The reaction mixture was allowed to warm to room temperature as the bath did (2 h). The mixture was treated with sat'd NH4Cl solution, and extracted with EtOAc. The organic layer was washed with brine, dried (sodium sulfate), concentrated, and purified by flash chromatography to give the title compound.

Provenance & Evidence