Sodium Iodide → HCID 59543146, compound

Participants

Reaction Steps

To a stirred solution of 1-{[(1R)-1-cyclopropyl-2,2,2-trifluoroethyl]amino}-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5H-pyrido[4,3-b]indole-4-carboxamide (0.17 g, 0.35 mmol) in THF (0.88 mL) and water (0.88 mL) were added chloramine T trihydrate (0.11 g, 0.39 mmol) and sodium iodide (0.079 g, 0.53 mmol). The reaction mixture was left to stir at room temperature for 2 h, diluted with EtOAc, and washed with water and brine. The organic layer was dried (sodium sulfate), concentrated, and purified by prep-HPLC to afford the title compound.

Provenance & Evidence