Trimethylsilylacetylene → HCID 59543128, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-{[(1R)-1-Cyclopropyl-2,2,2-trifluoroethyl]amino}-7-iodo-5H-pyrido[4,3-b]indole-4-carboxamide (0.19 g, 0.40 mmol), TMS acetylene (0.12 g, 1.2 mmol), Pd(PPh3)4 (0.047 g, 0.040 mmol), CuI (0.015 g, 0.081 mmol), and TEA (0.082 g, 0.81 mmol) in DMF (4 mL) was purged with nitrogen for 5 min, heated to 50° C. overnight, and cooled to room temperature. The mixture was diluted with EtOAc, washed with water and brine, dried (sodium sulfate), concentrated, and purified by flash chromatography to afford the title compound.

Provenance & Evidence