HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1971150Generated: October 27, 2026
1-Boc-5-Fluorospiro[indoline-3,4'-piperidine] → 1,1-Dimethylethyl 5-fluoro-1'-[2-hydroxy-2-(1-{[(phenylmethyl)oxy]carbonyl}-4-piperidinyl)ethyl]spiro[indole-3,4'-piperidine]-1(2H)-carboxylate
https://huagongshe.com/reaction/1971150
Participants
| Role | Name | HCID | Charge |
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| Reactant | 1-Boc-5-Fluorospiro[indoline-3,4'-piperidine] | HCID 49760960 | — |
| Reactant | Benzyl 4-(oxiran-2-yl)piperidine-1-carboxylate | HCID 59305139 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,1-Dimethylethyl 5-fluoro-1'-[2-hydroxy-2-(1-{[(phenylmethyl)oxy]carbonyl}-4-piperidinyl)ethyl]spiro[indole-3,4'-piperidine]-1(2H)-carboxylate | HCID 66938096 | — |
Reaction Steps
Phenylmethyl 4-(2-oxiranyl)-1-piperidinecarboxylate (990 mg) was added to a solution of 1,1-dimethylethyl 5-fluorospiro[indole-3,4′-piperidine]-1(2H)-carboxylate (1.16 g) in EtOH (20 mL). The reaction was heated to 95° C. for 7 h and then stirred at room temperature overnight. The solvent was removed and the title compound was obtained as crude oil. MS (ES) m/e 568 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08431590B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-7d07d99a542945aaa070962d1f2c6b1d |
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| Source note | uspto-grants-2013_04 |
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