1-(2-Fluoro-4-nitrophenyl)-2-pyrrolidinone → 1-(4-Amino-2-fluorophenyl)pyrrolidin-2-one

Participants

Reaction Steps

650 mg (2.9 mmol) of 1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-one (Example 14b) and 65 mg of Pd/C 10% are shacked in 15 ml of MeOH/THF (1:1) under 1.1 bar of H2 for 2 h at rt. After completion of the reaction, the catalyst is filtered-off and the filtrate is evaporated in vacuo to give the title compound as an off-white solid. ES-MS: 195 (M+H)+; analytical HPLC: tret=1.91 minutes (Grad 1).

Provenance & Evidence