2-Fluoro-5-nitrobenzotrifluoride → HCID 66870151, compound

HRID 1971233Notes

Reaction equation

HRID 1971233 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][CH2:5][C@@H:4]([CH3:8])[NH:3]1.F[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1[C:19]([F:22])([F:21])[F:20]>>[CH3:8][C@H:4]1[NH:3][C@@H:2]([CH3:1])[CH2:7][N:6]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=2[C:19]([F:20])([F:21])[F:22])[CH2:5]1

Participants

3

Reactant 2

HCID 949542-Fluoro-5-nitrobenzotrifluorideHCID 6950261rel-(2R,6S)-2,6-dimethylpiperazine

Product 1

HCID 66870151HCID 66870151, compound

Procedure

The title compound is obtained in a similar manner as described in Example 18b starting with cis-2,6-dimethylpiperazine (Aldrich, Buchs, Switzerland) and 2-fluoro-5-nitrobenzotrifluoride (Aldrich, Buchs, Switzerland). Title compound: ES-MS: 304 (M+H)+; analytical HPLC: tret=2.89 minutes (Grad 1).

Sources & evidence

ORD record
ord-ed98e321f8de41d5b9517cd6e6bbda27
Source dataset
uspto-grants-2013_04
Patent number
US08431592B2

Reaction notes

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