反应详情

温度

50 °C

To a solution of ethyl 5-[(adamantan-1-ylmethyl)carbamoyl]imidazo[1,2-a]pyridine-2-carboxylate (852 mg, 2.3 mmol) in MeOH (10 mL), is added 1 mL of 10 N NaOH aqueous solution. The reaction mixture is heated at 50° C. for 4 h. After cooling to RT, the solvent is removed in vacuo. The residue is diluted with water, and acidified with 2 N HCl aqueous solution until pH=3. Filtration affords the title compound.

1. temperatureAfter cooling to RT
2. customthe solvent is removed in vacuo
3. additionThe residue is diluted with water
4. filtrationFiltration