HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → trans-(5-(2-chloropyridin-4-yl)-4,5-dihydrooxazol-4-yl)(2H-pyrrol-1(5H)-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Chloro-4-pyridinecarboxaldehyde | HCID 2762994 | — |
| Reactant | 2-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone | HCID 57571251 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | trans-(5-(2-chloropyridin-4-yl)-4,5-dihydrooxazol-4-yl)(2H-pyrrol-1(5H)-yl)methanone | HCID 86626955 | 84% |
Reaction Steps
SLA 07158 was prepared in accordance with method D using 2-chloropyridine-4-carbaldehyde SLA 07156 (0.47 g, 3.31 mmol), KOH (0.184 g, 3.33 mmol) in methanol (10 mL) and 2-Isocyano-1-(2H-pyrrol-1(5H)-yl)ethanone SLA 07178 (0.410 g, 3.01 mmol). The solution was stirred 2 h with continued cooling. After work-up and column chromatography on florisil (EtOAc), trans-(5-(2-chloropyridin-4-yl)-4,5-dihydrooxazol-4-yl)(2H-pyrrol-1(5H)-yl)methanone SLA 07158 was obtained as a yellow solid (0.597 g, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431599B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d7dbca35862744bbbe3733725eea4162 |
| Source note | uspto-grants-2013_04 |