HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1971287Generated: October 25, 2026
Potassium Hydroxide → trans-(4,5-Dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone
https://huagongshe.com/reaction/1971287
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Reactant | Piperidine, 1-(isocyanoacetyl)- | HCID 6455474 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | trans-(4,5-Dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone | HCID 68961100 | 99% |
Reaction Steps
SLA 09052B was prepared in accordance with method D using thiophene-3-carbaldehyde (0.778 mL, 5.43 mmol), KOH (0.273 mg, 4.94 mmol) in methanol (5 mL) and 2-isocyano-1-(piperidin-1-yl)ethanone SLA 07116B (0.75 g, 4.94 mmol). The solution was stirred for 2 h at 0° C. After work-up (without any further purification) and drying trans-(4,5-dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone SLA 09052B was obtained as a yellow oil (1.29 g, 99% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08431599B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-9f5cf2b18bb7438f9a1c33d28ea63345 |
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| Source note | uspto-grants-2013_04 |
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