HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → Methyl 1-benzyl-2-methyl-3-oxopiperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 4-(benzyl(1-ethoxy-1-oxopropan-2-yl)amino)butanoate | HCID 67423852 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 1-benzyl-2-methyl-3-oxopiperidine-4-carboxylate | HCID 67423405 | — |
Reaction Steps
A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification. MS (ESI) m/z 262.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431584B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-71da6ccaf14f46f0b2c7d7ac63d050c0 |
| Source note | uspto-grants-2013_04 |