反应详情

400 mg (2.51 mmol) N-1,3-thiazole-2-yl-thiourea were suspended in 20 ml of methanol and 392 mg (2.76 mmol) methyl iodide were added. The reaction mixture was stirred for 4 hours at reflux. Following removal of the solvent by vacuum distillation, the residue obtained was dissolved in 20 ml ethanol, 1.72 g (12.6 mmol) 2-methoxybenzylamine were added and the mixture was stirred for 20 hours at reflux. The solvent was removed on the rotovap. The residue was separated by preparative HPLC (RP-18 column, eluent water/acetonitrile/0.1% acetic acid) and 380 mg N-(2-methoxybenzyl)-N′-1,3-thiazole-2-ylguanidine were obtained.

1. temperatureat reflux
2. customremoval of the solvent
3. distillationby vacuum distillation
4. customthe residue obtained
5. stirringthe mixture was stirred for 20 hours
6. temperatureat reflux
7. customThe solvent was removed on the rotovap
8. customThe residue was separated by preparative HPLC (RP-18 column, eluent water/acetonitrile/0.1% acetic acid)