2-Amino-4-phenylthiazole → n-[(4-Phenyl-1,3-thiazol-2-yl)carbamothioyl]benzamide

HRID 1971443Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1971443
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[C:13]([N:21]=[C:22]=[S:23])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CC(C)=O>[C:7]1([C:5]2[N:6]=[C:2]([NH:1][C:22]([NH:21][C:13](=[O:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[S:23])[S:3][CH:4]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 403022-Amino-4-phenylthiazoleHCID 68284Benzoyl isothiocyanate

Produkt 1

HCID 782761n-[(4-Phenyl-1,3-thiazol-2-yl)carbamothioyl]benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

3.10 g 2-amino-4-phenylthiazole (176 mmol) and 3.00 g benzoylisothiocyanate were heated in 50 ml acetone for 2 hours at reflux, during which a yellow solid was formed. The reaction mixture was subsequently stirred for 30 minutes at 5° C., the solid was suction-isolated and washed multiple times with n-pentane. After drying, 4.20 g of the target structure was obtained as an amorphous yellow solid.

Aufarbeitung

  1. temperatureat reflux, during which a yellow solid
  2. customwas formed
  3. customthe solid was suction-isolated
  4. washwashed multiple times with n-pentane
  5. customAfter drying
  6. custom4.20 g of the target structure was obtained as an amorphous yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-ba3825c6066746f894c0519345c56569
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431604B2

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