Methyl iodide → HCID 178503959, compound

HRID 1971464Notes

Reaction equation

HRID 1971464 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11]([NH2:13])=[S:12].[CH3:14][I:15]>CO>[I-:15].[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11]([S:12][CH3:14])=[NH2+:13]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 27710151H-benzimidazol-2-ylthiourea

Product 1

HCID 178503959HCID 178503959, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 0.27 g (1.40 mmol) N-1H-benzimidazole-2-ylthiourea were added 0.115 ml (1.83 mmol) methyl iodide dissolved in 4 ml of methanol. It was heated for 30 minutes at reflux. After completion of the reaction, the solvent was removed under vacuum and 0.47 g 1H-benzimidazole-2-ylamino)(methylthio)methane iminium iodide was used without further purification for the following reaction.

Workup

  1. temperatureIt was heated for 30 minutes
  2. temperatureat reflux
  3. customAfter completion of the reaction
  4. customthe solvent was removed under vacuum and 0.47 g 1H-benzimidazole-2-ylamino)(methylthio)methane iminium iodide
  5. customwas used without further purification for the following reaction

Sources & evidence

ORD record
ord-4f2fb512222f4dbd93551d310ebecdcb
Source dataset
uspto-grants-2013_04
Patent number
US08431604B2

Reaction notes

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