2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 178474420, compound

HRID 1971465Notes

Reaction equation

HRID 1971465 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=O.[C:12]([NH:15][C:16]([NH2:18])=[NH:17])(=[O:14])[CH3:13]>C(#N)C>[F:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:17]=[C:16]([NH:15][C:12](=[O:14])[CH3:13])[NH:18][CH:2]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 178475102HCID 178475102, compound

Product 1

HCID 178474420HCID 178474420, compoundYield 33.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3.00 g (13.82 mmol) 2-bromo-4′-fluoroacetophenone, 2.80 g (27.64 mmol) acetylguanidine and 15 ml acetonitrile were combined and were together brought to reaction in the microwave (at 100 Watt) for 60 minutes at 40° C. by “heating by cooling”. After cooling, the solid formed was filtered off of the solvent. In addition, a total amount of 1.02 g N-[4-(4-fluorphenyl)-1H-imidazole-2-yl]acetamide were isolated by fractional crystallization with ethanol of the remainder of the mother liquor.

Workup

  1. customwere together brought to reaction in the microwave (at 100 Watt) for 60 minutes at 40° C. by “
  2. temperatureheating
  3. temperatureby cooling”
  4. temperatureAfter cooling
  5. customthe solid formed
  6. filtrationwas filtered off of the solvent

Sources & evidence

ORD record
ord-a424b7a6600646b0858207a294eabe07
Source dataset
uspto-grants-2013_04
Patent number
US08431604B2

Reaction notes

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