Hydrochloric Acid → HCID 178491370、化合物

HRID 1971467ノート

反応式

HRID 1971467 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:5]=1[CH2:6][NH2:7].[N-:14]([C:17]#[N:18])[C:15]#[N:16].[Na+]>>[C:15]([NH:14][C:17]([NH:7][CH2:6][C:5]1[C:8]([O:12][CH3:13])=[CH:9][CH:10]=[CH:11][C:4]=1[O:3][CH3:2])=[NH:18])#[N:16]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 28008722,6-DimethoxybenzylamineHCID 4350929Sodium dicyanamide

生成物 1

HCID 178491370HCID 178491370、化合物

実験手順

15 ml 2N hydrochloric acid were added to 5.0 g (29.9 mmol) 2,6-dimethoxybenzylamine and the aqueous phase was subsequently removed under vacuum. The residue was then dissolved in 50 ml 1-butanol and 2.66 g (29.9 mmol) of sodium dicyanamide were added. The reaction mixture was heated for 5.5 hours at reflux and stirred for 12 hours at room temperature. The precipitate formed was filtered off, was washed with diethylether; 6.81 g.

後処理

  1. customthe aqueous phase was subsequently removed under vacuum
  2. dissolutionThe residue was then dissolved in 50 ml 1-butanol
  3. temperatureThe reaction mixture was heated for 5.5 hours
  4. temperatureat reflux
  5. customThe precipitate formed
  6. filtrationwas filtered off
  7. washwas washed with diethylether

出典と根拠

ORDレコード
ord-3f13ccd6b89e4534a76c3f6796092f92
出典データセット
uspto-grants-2013_04
特許番号
US08431604B2

反応ノート

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