Methyl iodide → HCID 178503992, compound

HRID 1971471Notes

Reaction equation

HRID 1971471 reaction equation
[C:1]([C:5]1[NH:9][N:8]=[C:7]([NH:10][C:11]([NH2:13])=[S:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:14][I:15]>CO>[IH:15].[C:1]([C:5]1[NH:9][N:8]=[C:7]([NH:10][C:11](=[NH:13])[S:12][CH3:14])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86761819(5-tert-butyl-1H-pyrazole-3-yl)-thiourea

Product 1

HCID 178503992HCID 178503992, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

270 mg (1.4 mmol) (5-tert-butyl-1H-pyrazole-3-yl)-thiourea were dissolved in 2 ml methanol, methyl iodide (202 mg, 1.4 mmol) was added and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated, dichloremethane was added to the residue and the mixture was stirred at room temperature. The solid was suction-isolated and dried (0.43 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additiondichloremethane was added to the residue
  3. stirringthe mixture was stirred at room temperature
  4. customThe solid was suction-isolated
  5. customdried (0.43 g)

Sources & evidence

ORD record
ord-56e247a13a524ddbbb687741bc3d7cb0
Source dataset
uspto-grants-2013_04
Patent number
US08431604B2

Reaction notes

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