Bromine → 2-Bromo-2'-chloroacetophenone

HRID 1971482Notes

Reaction equation

HRID 1971482 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 72864Ethanone, 1-(2-chlorophenyl)-

Product 1

HCID 27357852-Bromo-2'-chloroacetophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (3.8 mL, 65 mmol) was added dropwise to a solution of 1-(2-chloro-phenyl)-ethanone (10. g, 65 mmol) in acetic acid (75 mL) at 0° C. The mixture was then warmed to room temperature and stirred overnight. The mixture was evaporated to dryness and used in the next step without further purification.

Workup

  1. customThe mixture was evaporated to dryness
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-1518ac325aa74568a1f1e21796d701fd
Source dataset
uspto-grants-2013_04
Patent number
US08431605B2

Reaction notes

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