HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenylbutyric Acid → N-(6-Ethoxy-benzothiazol-2-yl)-2-phenyl-butyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenylbutyric Acid | HCID 7012 | — |
| Reactant | Amino-6-ethoxybenzothiazole, 2- | HCID 7192 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(6-Ethoxy-benzothiazol-2-yl)-2-phenyl-butyramide | HCID 4477449 | — |
Reaction Steps
6-Ethoxy-benzothiazol-2-ylamine (39 mg, 0.20 mmol) and 2-phenyl-butyric acid (33 mg, 0.20 mmol) were dissolved in N,N-dimethylformamide (1 mL) containing triethylamine (84.1 μL, 0.600 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (84 mg, 0.22 mmol) was added and the solution was allowed to stir for 16 hours. The crude product was purified by reverse-phase preparative liquid chromatography (17 mg, 0.050 mmol, 25%). ESI-MS m/z calc. 340.1. found 340.9 (M+1)+ Retention time 3.55 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431605B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-3266216ef30d4b8393a1472c4b30e26d |
| Source note | uspto-grants-2013_04 |