4-Methylbenzoyl Chloride → HCID 3534023, compound

HRID 1971510Notes

Reaction equation

HRID 1971510 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1.[CH3:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([NH:14][C:20](=[O:21])[C:19]2[CH:23]=[CH:24][C:16]([CH3:15])=[CH:17][CH:18]=2)[S:12][CH:13]=1

Participants

4

Reactant 2

HCID 134054-Methylbenzoyl ChlorideHCID 7352524-(2-Methoxy-phenyl)-thiazol-2-ylamine

Product 1

HCID 3534023HCID 3534023, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-(2-Methoxy-phenyl)-thiazol-2-ylamine (41.3 mg, 0.200 mmol) and 4-methyl-benzoyl chloride (30.9 mg, 0.200 mmol) were dissolved in 1 mL of pyridine. The reaction mixture was stirred at room temperature overnight and then purified by reverse-phase preparative liquid chromatography (7.32 mg, 0.0226 mmol, 11.3%). ESI-MS m/z calc. 324.1. found 325.2 (M+1)+ Retention time 3.75 minutes.

Workup

  1. custompurified by reverse-phase preparative liquid chromatography (7.32 mg, 0.0226 mmol, 11.3%)

Sources & evidence

ORD record
ord-8cf24b08f8a945ada867366160b94e73
Source dataset
uspto-grants-2013_04
Patent number
US08431605B2

Reaction notes

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