HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenylacetic acid → HCID 59589549, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenylacetic acid | HCID 15879 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 59589844 | HCID 59589844 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 59589549 | HCID 59589549 | — |
Reaction Steps
[5-(3-Amino-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (50 mg, 0.121 mmol), 3-chlorophenylacetic acid (25 mg, 0.145 mmol) and di-isopropylethylamine (25 μL, 0.145 mmol) were dissolved in dimethylacetamide (1 ml). HBTU (55 mg, 0.145 mmol) was subsequently added and the mixture was stirred overnight. The product was purified by preparatory HPLC. RT: 2.9 min, MI: 567, Method: 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431596B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4d9854a11a2f484793fce739d5500f94 |
| Source note | uspto-grants-2013_04 |