HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-methylpyridine → Ethyl 5-methylimidazo[1,2-a]pyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-methylpyridine | HCID 15765 | — |
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 5-methylimidazo[1,2-a]pyridine-2-carboxylate | HCID 821015 | 58.8% |
Reaction Steps
2-Amino-6-methylpyridine (5 g, 0.05 mol) was dissolved in tetrahydrofuran (100 mL). Ethyl bromopyruvate (9 g, 0.05 mol) was added and the mixture was refluxed for 4 hours. The reaction was cooled and the solid that formed was filtered to give 6 grams of 5-methylimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester. Rf 0.45, 2% methanol/dichloromethane; MS m/z 205 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431608B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-14eb88f6eb2848cfa9cf9535acbe2970 |
| Source note | uspto-grants-2013_04 |