Hydrochloric Acid → HCID 58124793, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 300 mg of 2d in 6 ml of dioxane was added a solution of 200 mg of KOH in 2 ml of water. The mixture was stirred at 50° C. for 1 hr. After cooling to RT, 25 ml of water was added and the reaction mixture was acidified to pH3 by addition of 0.5N HCl. The product was extracted into ethyl acetate. The organic layer was washed once with water, dried and concentrated, to provide 240 mg of 2e as colorless oil;

Provenance & Evidence