反应详情

A solution of 280 mg of 6b and 165 mg of 2b in 6 ml of acetic anhydride was heated in a microwave oven for 15 min at 140° C. The reaction mixture was cooled and residual solvents were removed by sequential coevaporation with toluene. The residue was purified by chromatography on silica gel, using a gradient of heptane/ethyl acetate as eluent, to provide 215 mg of 6c; MS-ESI: [M+1] 548.15.

1. temperatureThe reaction mixture was cooled
2. customresidual solvents were removed by sequential coevaporation with toluene
3. customThe residue was purified by chromatography on silica gel