Diethyl Ether → HCID 58124905, compound

Participants

Reaction Steps

A solution of 60 mg of 7k and 125 mg of 2-tributylstannyl pyrazine and 13 mg of Pd(PPh3)4 was heated in 2 ml of degassed toluene, under N2 atmosphere for 16 hr. The reaction mixture was concentrated and the crude material was chromatographed over silica gel, using a gradient of toluene/ethyl acetate as eluent. The material thus isolated was treated with diethyl ether, to provide 13 mg of crystalline 7m; Mp 267-268° C.; MS-ESI: [M+1] 529.3.

Provenance & Evidence