Tert-Butylamine → HCID 58124796, compound

Participants

Reaction Steps

A solution of 400 mg of 9d in 8 ml of tert-butyl amine was stirred for 3 days at RT; conversion was completed after that time. The reaction mixture was concentrated and the residue was treated with 30 ml of water and 30 ml of sat. NaHCO3 and the product was extracted into ethyl acetate. The combined organic layers were washed with water, dried and concentrated to provide 354 mg of 9e as essentially pure material, which was used without further purification in the next step. NMR (CDCl3) δ 1.12 (s, 9, tertC4H9), 2.88 (m, 4, 2×CH2), 3.52 (s, 2, CH2), 6.96, 7.18 and 7.22 (3×m, 3, thiophene-H).

Provenance & Evidence