Hydrochloric Acid → HCID 58124809, compound

Participants

Reaction Steps

A solution of 520 mg of 9f in 12 ml of dioxane and a solution of 330 mg of KOH in 2 ml of water were mixed and stirred for 4 h at ambient temperature. The reaction mixture was diluted with 20 ml of water and acidified with cold 0.5 HCl to pH3. The product was extracted into ethyl acetate. The extract was washed once with water, dried and concentrated to provide 480 mg of acid 9g as a colorless oil, which was used without further purification in the next step.

Provenance & Evidence