1,2-Dimethoxyethane → HCID 50938851, compound

Participants

Reaction Steps

A mixture containing 20 mg of 9j, 6 mg of pyridine-3-boronic acid and 10 mg of K2CO3 and 6 mg of Pd(PPh3)4 in 2 ml of degassed 90% aq. dimethoxyethane was heated under N2 for 16 h. The reaction mixture was cooled and diluted with water. The product was extracted with ethyl acetate. The extract was dried, concentrated and the residue was purified by chromatography over silica gel, using heptane/acetone as eluent. The isolated product was treated with ether/ethyl acetate (9/1 v/v) to give 14 mg of white crystalline 9k; Rf 0.50 (heptane/acetone 1/1);

Provenance & Evidence